Starting Cutscene
The level starts with a cutscene which shows Father and Carter trapped, but not injured. Father lied!
Make your way through the sewer. You will encounter a few small enemy spiders, nothing really important.
Continue walking in the sewer until you come across the end of the sewer tunnel. Now you can finally exit this dark place.
After the talk with Father ended, you will see your objective.
Get to the Vatican Library
No, you cannot get to the other side of the river, there’s an invisible wall there.
Snipers
Since you’re in the open now, you better look out for enemies. There are 2 snipers in front of you on the bridge. Better take care of them quickly, because they actually deal a lot of damage!
Also, Processed are coming your way. If you’ve taken care of them, you have peace… But only for a short amount of time. Go under the bridge and more enemies will spawn, including Gnaars and Drones.
If you walk till the very end of the sidewalk of the river, you will see a small 1HP. Pick it up, you’ll need every bit of health! Suddenly you hear Kamikaze screaming. Turn around and take care of them, before they take care of you.
1HP Kamikaze Trap
You can also just jump into the water, and they cannot get you. Now get up the stairs and there you can pick up some ammo and also get your first side mission in this level.
On the left side there is a person standing, go to him to activate the side mission.
Side mission: Gabriella’s Knight
The old guy says something about his daughter requiring help. And because you’re such a gentleman, you will help!
To find Gabriella, just follow the blue waypoint on the left. But be freaking careful, there are enemies out there!
After finishing them off, go left to enter a new area, where you will find a witch bride attacking you.
There are also some other enemies who want to eat your flesh. At some location in this area you can enter a warehouse.
Letter
Also make sure to look around you, because there is a room where you can read a letter.
Head back to the main hall to encounter more enemies. Gear up and prepare for battle as you clear out the area.
Once the enemies are dealt with, proceed to the door where you’ll meet a woman named Gabriella. After your conversation with her, you’ll complete the side mission Gabriella’s Knight.
Since the left path is inaccessible, take the right path instead. Here, you’ll find a radio that plays some dialogue. You can choose to listen to it or proceed straight ahead to a large open space.
In this area, soldiers will be firing at you, and there’s some ammo nearby to help you out. Brace yourself for a more intense fight as werebulls, khnums, and other enemies join the fray.
Once victorious, the gate ahead will open automatically. Inside, you’ll find a skill point—choose your desired skill and continue onward.
Skill point
A new radio will appear, but be warned: in some playthroughs (like mine), this radio may be bugged, and no dialogue will play. If this happens, simply move forward.
As you progress, more enemies will appear, along with helicopters that start spawning. Take them down and keep moving forward.
You’ll come across a new side mission called Worm’s Armageddon.
Side Mission – Worm’s Armageddon
This involves speaking with someone who is living in their basement.
Follow the blue waypoint to reach the side mission’s destination. Along the way, you’ll face more enemies, so stay alert.
Once you reach the building, enter it and head to the wall to pick up an item called Hypermebendazole. Then, backtrack to the small window of the basement where the old man resides. Deliver the item to complete the side mission Worm’s Armageddon.
Now that the side mission is complete, follow the yellow waypoint and jump down into the ruins. Be prepared—kamikazes will spawn immediately and attempt to take you out. Eliminate them and move forward.
You’ll soon come across another open space with plenty of cover spots. A swarm of snipers will attack you here, but they won’t be alone.
Reptiloids and other enemies will also join the fight. Use your surroundings wisely and take them all out.
Once all enemies are defeated, the gate ahead will open. Move forward slightly to trigger a cutscene.
ending cutscene
In this cutscene, you’ll meet a friendly lady who will provide some additional context for your mission. This marks the end of Chapter 7 When in Rome.
You’ve successfully completed Chapter 7: When in Rome in Serious Sam 4.